European Journal of Biomedical and Pharmaceutical Sciences

IN-SILICO STUDIES ON HUMAN REPRODUCTIVE HORMONES AND INTERACTIONS WITH ORGANOPHOSPHATE

Venkat Reddy Banda, Shyam Perugu, Rajesh Kumar K. and Sukesh Narayan Sinha*

ABSTRACT

Exposure of humans and wildlife to pollutants released in the environment is a centre of attention nowadays. Lots of of these chemicals (generally referred to as environmental pollutants) have been shown to hamper with normal hormonal signaling and natural biological functions, leading to reproductive disorders or infertility, which has been a matter of concern within the recent decades. From the literature reviewed that pollutants appear that environmental toxicants, especially heavy metals and organic chemicals of synthetic and microbiological origins, disrupt hormone production and action in the mammalian testes. The endocrine effects of long-term, low-level exposure to organophosphate (OP) and Phosposulphate compounds in our current investigations has proven that changing the organophosphate position on the hormones such as progesterone, testosterone, estradiol and molecular simulation studies evidenced for the stability of the structures when changing the R-groups on scaffolds with Energy minimization and RMS score. This study was undertaken to evaluate and predict the potential endocrine disrupting activity of the three most commonly sexual hormones in male and female due to exposure of organo phosphate compounds.

Keywords: Exposure of humans and wildlife Phosposulphate organo phosphate compounds.