European Journal of Biomedical and Pharmaceutical Sciences

CLINICAL TRIAL OUTCOMES OF SIDDHA FORMULATION PUNGAMPOOCHOORANAM ON ITS EFFICACY AGAINST DIABETES MELLITUS – TYPE II (MADHUMEGAM): AN OPEN LABEL CASE STUDY IN 40 PATIENTS

J. Nisha*, N. Anbu, N. J. Muthu Kumar and V. Banumathi

ABSTRACT

Diabetes Mellitus- Type II (DM-Type II) commonly known by its name Madhumegam in Siddha is a disease that affects more than 400 million people around the world. In 2040, there will be more than 640 million people with diabetes worldwide. The prevalence of TIIDM is expected to double within the next 20 years, due to the increase of the age, obesity and the number of ethnic groups of high risk in the population, with significant increases in cardiovascular disease, End-Stage Renal Disease (ESRD).Conventional anti-diabetic drugs used for clinical management of DM-Type II offers certain potential adverse effects upon long term usage which includes ketoacidosis, nausea, skin rashes, dermatitis, hypoglycemia etc. The use of herbal medicinal products and supplements has increased tremendously over the past three decades with not less than 80% of people worldwide relying on them for some part of primary healthcare. The main aim of the present investigation is to evaluate the anti-diabetic potential of the siddha formulation PungampooChooranam (PPC) in patients with TIIDM. A total of 40 patients who are recently identified with Type II diabetes along with secondary complication have been selected for the trial and were treated with PPC for the period of 48 days. The outcome of the study indicates that there was a significant reduction in clinical conditions such as Polyuria, Polyphagia, Polydipsia, Pruritis except emaciation among the patients. Structured monitoring of blood glucose is a greater systematic approach to the patient with TIIDM. It was observed from the data’s of the present study that there was significant decrease in fasting and post prandial blood glucose level along with HbA1c level in patients treated with trial drug. Hence from the study it was concluded that the trial drug PungampooChooranam was therapeutically effective in clinical management of TIIDM (Madhumegam).

Keywords: Type II diabetes mellitus, Madhumegam, PungampooChooranam, Fasting blood glucose, Post prandial blood glucose, HbA1c level.