Abstract
ASSOCIATION OF XPD LYS751GLN POLYMORPHISM WITH GASTRIC CANCER RISK IN KASHMIRI POPULATION

Bushra Nissar, Showkat A. Kadla, Falaque UL Afshan, Misbah, Idrees A. Shah, and Prof. Bashir Ahmad Ganai*

ABSTRACT

Genetic polymorphisms in several DNA repair genes can affect the capacity of DNA repair and are therefore associated with susceptibility to many cancers, including gastric cancer. In the present study, polymorphic variants of the DNA repair gene, XPD Lys751Gln was studied in association with the gastric cancer risk in Kashmiri population. A total of 60 histologically confirmed GC patients and matched controls were recruited for the study who underwent surgical resection. The genotyping of XPD gene was carried out by polymerase chain reaction-restriction fragment length polymorphism. In conclusion, polymorphic variants of XPD Lys751Gln (O.R=1.041, 95% C.I=0.25 - 4.26) were not found to be associated with the risk of gastric cancer in Kashmiri population. However, further studies will be needed with a larger sample size to authenticate these findings.

Keywords: DNA repair, Gastric cancer, Kashmir, Polymorphism, XPD.


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