European Journal of Biomedical and Pharmaceutical Sciences

ROLE OF HERBAL ANTIOXIDANT HEMIDESMUS INDICUS IN TREATMENT OF ANXIETY DISORDER

Dr. Sangita Jogdand, Dr. S. S. Patel, *Dr. Raju Shinde, Dr. Jagruti Bhattacharji, Dr. Mugha Padhye

ABSTRACT

Background: Plant derived medicines due to their less side effects, may have importance in future of medicinal system as 80% population is in favour of traditional medicine as per WHO, hence role of herbal antioxidant Hemidesmus indicus was studied in management of anxiety disorder. Methods: Newly diagnosed patients of mild to moderate anxiety disorder divided into two groups having forty patients in each group were enrolled. Group-I patients were given Tablet Clonazepam 0.5 mg orally daily for six months. Group-II patients were given Tablet Clonazepam 0.5 mg orally at night with Tablet Hemidesmus indicus 50 mg/kg in three divided doses for six months. Levels MDA, SOD and anxiety score was assessed at start of study and thereafter every month for six month. Result: Group-I patients showed significant increased MDA levels from 18.80 ± 0.37 to 27.97± 0.81, decreased SOD levels from 0.143± 0.004 to 0.111± 0.004 and decrease in anxiety score from 12.44± 1.24 to 2.55±0.72 after six months of treatment. In Group-II patient decrease in MDA levels from 18.81± 0.73 to 12.06±0.72 and increased SOD levels from 0.141± 0.005 to 0.185±0.004 after six months of treatment. Significant decrease in mean anxiety score from 12.54 ± 1.26 to 1.40 ± 0.68 was observed after first month onwards. Conclusion: Patients treated with Clonazepam show increase in oxidative stress though they were effective in reducing anxiety score. In Group-II patients, significant decreased oxidative stress and anxiety score was observed which may be because of antioxidant property of Hemidesmus indicus.

Keywords: Anxiety disorder, oxidative stress, anxiety score, Clonazepam, Hemidesmus indicus.