Abstract
A STUDY ON ANALGESIC ACTIVITY OF VALERIANA WALLICHI (TAGARA) WITH COMPARISON TO STANDARD DRUG PIROXICAM IN MALE ALBINO RATS

Lakshmi Deepika, Dr. P. Jagadeesh* and Dr. P. Vijayalakshmi

ABSTRACT

Background: Aim and objectives: the present study was carried out 1) To evaluate the analgesic activity of Valeriana wallichi in Male Albino rats. 2) To compare the analgesic activity of Valeriana wallichi with a standard drug Piroxicam in Male Albino rats. Materials and methods: Digital analgesiometer was used to evaluate analgesic activity of marketed preparation of Valeriana wallichi (Tagara from Himalaya Herbal products) by tail flick method. Male wistar albino rats weighing 150 - 250g are divided into 3 groups consisting of 6 rats in each group. First group of rats (control group) were treated with 0.2 ml normal saline orally. Second group were designated as standard group and were treated with 2mg/kg of Piroxicam orally. Third group were designated as test group and were treated with 120mg/kg of Valeriana wallichi orally. One way ANOVA was used for statistical calculation. Results: The test drug Piroxicam and the standard drug Valeriana wallichi showed significant analgesic activity and the analgesic activity of Piroxicam is higher when compared to V. wallachi. Conclusion: Valeriana wallichi showed significant analgesic activity.

Keywords: Analgesic, Valeriana wallichi, Piroxicam, Tail flick method, Digital analgesiometer.


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