European Journal of Biomedical and Pharmaceutical Sciences

REVIEW ON NANOSUSPENSION: AN EMERGING TECHNOLOGY

Ankita Sarma*, Dr. Abdul Baquee Ahmed and Dr. Smiritirekha Chanda Das

ABSTRACT

Solubility is the vital factor for drug effectiveness, independence of the route of administration. Many of the newly discovered drugs are poorly soluble and they create major problems during formulation which shows poor bioavailability. The problem is even more complex for drugs which belong to BCS Class II category. To overcome these problems nanotechnology is used to improve the solubility as well as bioavailability of poorly soluble drug. Nanosuspensions can be defined as the submicron colloidal dispersions of selected drugs in a liquid medium, size range below 1μm (10-9 metre), without any matrix material which are stabilized by polymers and surfactants. Nanosuspensions are prepared by using mainly two techniques: top down and bottom up technique which include wet mill, high pressure homogenizer, emulsion‐ solvent evaporation, melt emulsification method and super critical fluid techniques etc. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes. Due to its numerous advantages nanosuspension technology can be regarded as a promising drug delivery system. This review article describes the preparation method, characterization, applications of the nanosuspension.

Keywords: Nanosuspension, preparation techniques, Oral bioavailability, Application.