European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION DEVELOPMENT AND EVALUATION OF OLMESARTAN MEDOXAMIL ORORETENTIVE JELLIES

S. Sarojini*, K. Anusha, Ch. Maneesha, M. A. Mufaquam, B. Mounika, Y. Krishna Reddy, M. Bhavana, B. Deepika and K.Rajeswar Dutt

ABSTRACT

Convenience of administration and patient compliance are gaining significant importance in the design of dosage forms. Olmesartan Medoxamil is an orally administered antihypertensive agent, used in the management of hypertension. Difficulty in swallowing (dysphagia) is common among all age groups, especially in elderly and pediatrics. Persons suffering from dysphagia may get choked when they consume liquid formulations, thus to alleviate such problem liquid formulation of high viscosity were prepared. Formulation of oral soft gel (batches of Olmesartan medoxamil) were prepared by using hydrophilic polymer almond gum and gelatin at three different concentration. The prepared batches were evaluated for appearance, viscosity, pH, drug content, syneresis and in vitro drug release. The optimized batch F5 were to be subjected to short term stability study for three months. The problem of dose measurement by patients was outweighed as oral medicated gels are to be packed in unit dose container.

Keywords: Hypertension, medicated Jelly, Dysphagia, (OSML) Olmesartan medoxamil, almond gum, gelatin.