FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLES OF QUETIAPINE FUMARATE BY HOT HOMOGENIZATION METHOD
Hari Anushree and P. Tripura Sundari*
ABSTRACT
The aim of the present study is to formulate and evaluate solid lipid nanoparticles of Quetiapine Fumarate. Quetiapine Fumarate is an antipsychotic drug used in the treatment of Schizophrenia. Quetiapine Fumarate has poor water solubility and oral bioavailability of 9% due to first pass metabolism. To overcome these problems an attempt was made to prepare Quetiapine Fumarate into Solid lipid nanoparticles which has ability to improve the solubility and enhance the oral bioavailability. In the present study Quetiapine Fumarate loaded SLNs was prepared by Hot Homogenization method. The Cutina® HR was used as the Lipid, Gelucire 50/13 as lipophilc surfactant and Kholliphor P 188 as Hydrophilic surfactant in the preparation. The five prepared formulations were evaluated for various parameters like entrapment efficiency, In Vitro drug release, particle size, Zeta potential and Stability studies. Among all the Preparations H2 formulation was best in terms of Entrapment efficiency of 88.6%, Drug release of 88.1%, Particle size of 99.6 nm with Zeta potential of -42 mV in Hot Homogenization. The present study conclusively demonstrated that the solubility of drug was improved by entrapment of drug into solid lipid carrier which led to prolongation of drug release.
Keywords: Solid Lipid Nanoparticles, Quetiapine Fumarate, Cutina® HR.
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