Abstract
FORMULATION AND EVALUATION OF FLOATING BIOADHESIVE TABLETS OF BALOFLOXACIN

S. Indira*, Dr. P. Amareshwar and Dr. Prathima Srinivas

ABSTRACT

A new gastro retentive sustained release delivery system for Balofloxacin was developed by utilizing the concepts of both bioadhesion and floatation due to which the gastric residence time increases and hence improving the bioavailability. Floating bioadhesive tablets were formulated by using various bioadhesive agents like carbopol, guargum and xanthan, HPMC K4M as the retarding polymer and Sodium bicarbonate as the effervescent agent in different proportions were tried and optimized on basis of drug release and bioadhesive property. Balofloxacin is a BCS Class – II wide spectrum antibiotic active against both gram positive and gram negative bacteria. The ideal properties like solubility of Balofloxacin in the stomach and biological half-life of 7 hrs are suitable for formulating it into a Gastro retentive sustained release drug delivery system. The prepared tablets were evaluated for weight variation, friability, drug content, in-vitro drug release, bioadhesive property and swelling index. The tablets exhibited satisfactory physical parameters and good in vitro buoyancy. It was found that all the post compressional parameters were within the limits. The in-vitro drug release and bioadhesion strength were found to be increased with the increase in adhesive polymer concentration.

Keywords: Gastroretentive drug delivery system, Balofloxacin, Carbopol 934, Bioadhesion, Drug-Release


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