European Journal of Biomedical and Pharmaceutical Sciences

ANTIBIOTIC EXPOSURE PROFILE AND PRACTICAL WAYS OF USE AT THE HEART INSTITUTE OF ABIDJAN

Koffi Armand Angely*, Nguessan Clemence, Aka Sandrine, Tuo Awa and Say Assemian Camile

ABSTRACT

Introduction: This retrospective study was conducted at the Heart Institute of Abidjan (ICA) in Côte d'Ivoire over a period of 10 months (January to October 2010). The general objective was to determine the socio-demographic and pathological profile of hospitalized patients in the medical and intensive care units who received antibiotic therapy during the study period and then to evaluate the practical modalities of prescribing these antibiotics. Methods: The study was conducted along two lines: a documentary review of patient records and a clinical audit of the compliance of prescriptions with clinical practice recommendations. The ATC / DDJ (Therapeutic and Chemical Anatomical / Defined Daily Dose) analysis recommended by the WHO was used. Results: 70% of patients receiving antibiotic therapy at ICA belonged to the medical and intensive care units. These patients were generally between 36 and 75 years old. They were mostly male (sex ration 2.27). The main indications for antibiotic therapy were pneumonia (40%), pericarditis (16%) and COPD (9%). The most prescribed family of antibiotics was penicillins and mainly amoxicillin / clavulanic acid, which had a penetration rate of 180.37. The antibiotic exposure rate was 72.8%. 28% of the prescriptions were not in conformity with the recommendations. These non-compliances included the indication (20.7%), the dosage (5.7%), the duration of treatment (1.9%) and the route of administration (2.5%). Conclusion: The results confirmed the difficulties of prescribing antibiotics in the context of cardiovascular infections. The periodic evaluation of the anti-infective prescription should be recommended for surveillance of nosocomial infections and reduction of hospital costs.

Keywords: Antibiotic therapy, exposure profile, cardiovascular infections.