Abstract
ASSOCIATION OF HYPERURICEMIA WITH PREECLAMPSIA: IS SERUM URIC ACID A GOOD PREDICTOR OF PREECLAMPSIA ? KHARTOUM, SUDAN

*Azza A. Zulfu, MD

ABSTRACT

Background: Preeclampsia is an important cause of fetal and maternal mortality and morbidity worldwide. Hyperuricemia is a common finding in preeclampsia. Serum uric acid measurement is widely used and investigated for the prediction, diagnosis, follow up and management of pre- eclampsia. The objective of this study is to investigate the association of serum uric acid with preeclampsia and its possible value in predicting preeclampsia. Materials and Methods: This is a case control, cross sectional, hospital based study. Serum uric acid was measured for 50 pregnant women diagnosed with preeclampsia and 50 normotensive women in the third trimester at Khartoum Teaching Hospital (KTH), Obstetrics & Gynecology Department during June 2011 March 2012. Results: The mean serum uric acid for the preeclampsia case group was 7.35mg/dl and for the normotensive group was4.47mg/dl. Statistical probability value and correlation coefficient testing show significance in relationship between blood pressure and serum uric acid level; and for hyperuricemia and preeclampsia (P value =0.000., t test =0.6 is significant). Conclusion: Preeclampsia is associated with hyperuricemia. Serum uric acid can be used as a predictor of preeclampsia.

Keywords: Serum uric acid, preeclampsia.


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