SPERM PARAMETERS AND TESTOSTERONE LEVELS OF SPRAGUE DAWLEY RATS WITH PALA KALYANA GHRITA : A TRADITIONAL FORMULA
Kariyakeranage Chandi Perera*, Sumeda Wijeratne, Dilani Lokuhetty, Deepal Mathew
ABSTRACT
Pala Kalyana Ghrita (PKG) is a poly herbal formula used for enhancement of fertility by traditional medical practitioners from ancient times. However, the scientific evaluation of this natural herbal medicine is yet to be explored. The present study was under taken to evaluate pharmaceutical significance of PKG on some fertility parameters of male Sprague Dawley rats. Eighteen rats were randomly divided into three groups (n = 6 /group). The control group, (Group I) received only distilled water. Groups II and III were orally administered with 900 mg and 1800 mg of PKG / kg body weight respectively, once daily, for 12 weeks. Pretreatment mean body weight and Post treatment mean body weight, mean testicular weight and sperm parameters were measured. Although there was no significant difference in mean body weights of the rats included control and the treatment groups prior to treatment, a significantly higher mean body weight of both the treatment groups (248.83 ± 1.60 and 252.50 ± 1.63) than the control group (231.33 ± 6.80 g) (p = 0.003) was observed after the treatment period. . The testicular weights of both treated groups were also significantly higher than that of the control group. Similarly, serum testosterone level of both treated groups (3.46 ± 0.69 ng/mL and 4.98 ± 2.1 ng/mL) was elevated compared to the control group (1.33 ± 0.11ng/mL) (p = 0.001). PKG has fertility enhancing effects as evident by increasing in mean testicular weight, testosterone level and sperm parameters of male Sprague Dawley rats in the treated groups.
Keywords: Palakalyana Ghrita, Spermatogenesis, Testosterone, Testis.
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