European Journal of Biomedical and Pharmaceutical Sciences

INCIDENCE OF ACUTE LYMPHOBLASTIC LEUKEMIA, EXPERIENCE AT KING HUSSEIN MEDICAL CENTER (KHMC). JORDAN

Ahmad Bani Salameh, MD, Rima Nserat MT, Mansour Hyari, MD, Mohammad Maayta, MD, Bayan Zgoul, MD, Hala Alsokhni, MD, Asim Momani, MD, and Rame Khasawneh, MD

ABSTRACT

Aim of the study: To evaluate the incidence of newly diagnosed cases of acute lymphoblastic leukemia, and to examine the relation of ALL incidences with patient's AN. Methods: This is a retrograde statistical study, all data was retrieved from the lab records at the Hematopathology Department / Princess Iman Center for Research and Laboratory Sciences/KHMC over a 6 years period (2008-2014). For each patient's complete blood count, bone marrow aspirate, flowcytometry, and cytogenetic study were performed. Results: Total number of newly diagnosed cases is 94 (including both adults and children), of which 82 cases are B-ALL, 11 cases are T-ALL and 1 case undifferentiated ALL. 92% of cases are in the age group of 1-13 years with the peak in the age group of 2-3 years. Of the 94 cases, males are 54 and females are 40 with an M: F ratio of 1.4:1. 53 patients show no cytogenetic abnormalities; 34 males and 19 females while 41 patients show cytogenetic abnormalities; 20 males and 21 females. Conclusion: incidence of acute lymphoblastic leukemia appeared comparable with global published data. Morphological and cytogenetic findings in association with age and gender revealed that B-ALL more frequently than T-ALL. The peak incidence was in male children 2-3 years age which is keeping with global statistics.

Keywords: leukemia, incidence, bone marrow aspirate.