European Journal of Biomedical and Pharmaceutical Sciences

PHYSIOLOGICAL CHANGES IN SEX HORMONES OF OSTEOPOROSIS WOMEN IN BASRA PROVINCE/IRAQ

Mustafa Abd-Almajeed Hussein* and Sami Jiber AL-Maliki 

ABSTRACT

Osteoporosis is the most common bone disease in humans, it is characterized by low bone mass, deterioration of bone tissue and disruption of bone architecture, compromised bone strength and an increase in the risk of fracture. Various endocrine factors, including gonadal sex hormones influence bone growth. Estrogen deficiency accelerates the rate of bone turnover, thereby altering the balance between bone formation and bone resorption, Sex hormones have important effects on bone, especially in postmenopausal women, these hormones may be of particular significance in patients with osteoporosis disease, postmenopausal bone loss is thought to be due to the cessation of ovarian estrogen production, and cyclic estrogen replacement has been shown to prevent this bone loss. Ninety five women patients referring from urban and rural housing in Basra province aging between (50-69) years old visit al zahraa clinic in Ibnalbitar private hospital to determine the percentage of bone density by measuring the bone mineral density of lumber spine and hip by a dual energy x-ray absorptiometry (DEXA) from Lunar Prodigy (version 16) (USA). Venous blood sample was taken from each patient after diagnosing of disease by using DEXA machine, then the sex hormones include estrogen, progesterone, testosterone, FSH and LH was estimated by using VIDAS automated quantitative test. The results shows significant decrease (p≤0.05) in estrogen and progesterone and significant increase (p≤0.05) in FSH and LH while no changes occurs in testosterone compared with healthy women. In conclusion, sex hormones have significant changes in osteoporosis women in Basra province / Iraq.

Keywords: osteoporosis, sex hormones, estrogen, progesterone, DEXA.