ANTIDIABETIC, ANTIHYPERLIPIDAEMIC AND ANTIOXIDANT ACTIVITIES OF LEAVES OF LEUCAS LINIFOLIA SPRENG IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Dr. Mukundam Borah* and Dr. Swarnamoni Das
ABSTRACT
Objectives: The leaves of Leucas linifolia Spreng. are used in folk medicine to treat diabetes. The objective of the study was to evaluate the antidiabetic, anti-hyperlipidemic and anti-oxidant activities of the ethanolic extract of the leaves of Leucas linifolia Spreng. (EELL) in streptozotocin induced diabetic rats. Materials & Methods: Male Wistar albino rats (150–200g) were administered single intraperitoneal injection of STZ (60 mg/kg b.w. i.p) to induce diabetes. Albino rats (n=25) were divided into five groups of five animals each. Group I
(Normal control) and Group II (Diabetic control) received normal saline (10ml / kg / day p.o) whereas Group III and Group IV received 250 mg/kg/day and 500 mg/kg/day p.o of EELL respectively for two weeks. Group V (Diabetic standard) received 6 U/kg /day s.c of NPH insulin. Biochemical estimations of fasting blood sugar, serum insulin, catalase, malondialdehyde and serum lipid profile were performed on 1st, 8th and 15th day. Effect of EELL on intestinal glucose absorption was also evaluated. Results: Group II exhibited significant rise in blood glucose, serum cholesterol, triglycerides, Low density lipoprotein, serum malondialdehyde levels and decrease in serum insulin, catalase and High density lipoprotein levels. EELL treated groups showed reversal of these changes significantly (p <0.01)after 2 weeks. EELL increased serum insulin levels (p <0.01) and also a decrease in intestinal glucose absorption (p <0.01).Data were analyzed statistically by using one way ANOVA followed by Tukey’s post hoc test. Conclusion: EELL possess significant antidiabetic antihyperlipidaemic and antioxidant activities in streptozotocin induced diabetic rats.
Keywords: Streptozotocin, insulin, ethanolic extract, EELL.
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