A REVIEW ON CONTROLLED POROSITY OSMOTIC PUMP AS AN OSMOTIC DRUG DELIVERY APPROACH
Sakina A. Khan*, Ajay N. Talele, Dr. Sachin B. Narkhede and Mrinanka Singha
ABSTRACT
Oral route is found to be more convenient route. But the inability of conventional system to utilize this route efficiently lends the pharmaceutical market for more appropriate option i.e. controlled drug delivery system which can maintains plasma drug concentration. Osmotic drug delivery is found to be superior out of them that utilize the principle of osmotic pressure to maintain the drug release at zero order rate. The drug releases is independent of the pH and thermodynamics of dissolution medium and zero order kinetics. The release of drug from Osmotic system depends upon various formulation factors like solubility, osmotic pressure (core components), size of the delivery orifice and nature of the rate controlling membrane. CPOP constitutes drug, osmogens, excipients in core and a coating of semipermeable membrane containing water soluble additives (Pore former). In CPOP pore former dissolve after coming in contact with the body fluids, resulting in an in situ formation of a microporous membrane due to the pore formers. The present study gives a glimpse about osmotic drug, CPOP, components of CPOP, factors influencing drug release from the system and its evaluation.
Keywords: CPOP, Osmotic tablets, Controlled release drug delivery, Pore former, Microporous system
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