European Journal of Biomedical and Pharmaceutical Sciences

BIOGENESIS OF GOLD NANOPARTICLES, ROLE OF FUNGAL ENDOPHYTES AND EVALUATION OF ANTICANCER ACTIVITY- A REVIEW

M. Uzma1, Vinay B. Raghavendra* and S. T. Girisha

ABSTRACT

Due to the surge of interest in synthesizing nanoparticles in the recent couple of years using green routes, the field of nanotechnology has been advanced in the production of different metal nanoparticles which in turn have found innovative applications in various fields. These advances in turn provide an alternative for physicochemical methods of nanoparticles formation economically. Metals like gold and silver have been used for the biosynthesis of nanoparticles due to which they have attained a special focus. Gold nanoparticles have received tremendous importance in research because of their unique optoelectrical and photothermal properties. The scanty reports of nanomaterial synthesis from fungal endophytes have led to the development of „myconanotechnology‟ as a new emerging domain of nanotechnology. This emerging field of nanoparticles synthesis using endophytic fungi is advantageous as fungi have the ability to produce large amount of nanoparticles by secreting large amount of enzyme proteins which can prevent the fast depletion of plant sources. Apart from this, fungus provides protection and survival condition to their host plants. Although many fungi have been reported as nano-biofactories of gold metal, relatively few reports are available about the synthesis of nanogold using fungal e; ndophytes. The present review is of a kind wherin it gives a vision of biogenic gold nano synthesis, unexplored endophyte-mediated gold nanomaterials and anticancer activity of green synthesized nanoparticles.

Keywords: Fungal endophytes, Gold nanoparticles (AuNP?s), Green synthesis, Anticancer activit.