INVITRO ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF NITRITO-O COMPLEX OF Hg(II) WITH BENZIMIDAZOLE
*T. Gomadurai, K. Rajasekar, P. Manikandan, S. Balasubramaniyan and C. Veeravel
ABSTRACT
Transition metal complex of Benzimidazole (Bz) and nitrito-O (NO2) ligands was synthesized and characterized based on elemental analysis, metal estimation, molar conductance, cyclic voltammetry, solid state reflectance (UV-Spectra), IR, Far-IR and NMR spectra. The data obtained from elemental analysis, metal estimation and molar conductance the proposed general formula of the complex is [M(L1)2(L2)2] where M = Hg(II), L1 – Benzimidazole and L2 – Nitrite ion ( Nitrito-O). The complex is neutral in nature. Solid state reflectance depicts the tetrahedral geometry of the complex. Metal- chelate and complexation ability confirmed by their IR and Far-IR spectral data. Nuclear magnetic resonance spectra (1H-NMR & 13C-NMR) conveniently predict the geometry of the complex. The mixed ligand complexes were evaluated for their biological activities against the bacterial strain Klebsiella Pneumonia and the fungal strain C.albicance. The complex was found to very good antibacterial and antifungal activities compared to the Benzimidazole ligand.
Keywords: Hg(II) complex, Benzimidazole, Nitrito-O, Klebsiella Pneumonia and C.albicance.
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