Abstract
EVALUATION OF ANTIASTHMATIC ACTIVITY OF ETHANOLIC EXTRACT OF GYMNEMA SYLVESTRE L. LEAVESEVALUATION OF ANTIASTHMATIC ACTIVITY OF ETHANOLIC EXTRACT OF GYMNEMA SYLVESTRE L. LEAVESEVALUATION OF ANTIASTHMATIC ACTIVITY OF ETHANOLIC EXTRACT OF GYMNEMA SYLVESTRE

Kanakam Vijayabhaskar*, Kalakota Chaitanya Prasad, Gugloth Himabindu, Mohammed Abdul Mateen, Puram paramesh, Kyatham Hemanth

ABSTRACT

Present study, ethanol extract of G. sylvestre leaves was evaluated for antiasthmatic activity using histamine and acetylcholine-induced bronchospasm, mast cell degranulation and histamine induced constriction on isolated guinea pig tracheal chain at different dose levels. Student's t-Test and Dunett's test were used for statistical analysis.The result of present investigation showed that the ethanolic extract of G. sylvestre significantly (P<0.001) decreased the bronchospasm induced by histamine, acetylcholine and protected mast cell degranulation as compared to control groups. It also decreased the histamine induce constriction on isolated guinea pig trachea in dose-dependent manner. The present study concludes that the antiasthmatic activity of ethanolic extract of G. sylvestre leaves may be due to the presence of flavonoids or steroids. Antiasthmatic action of the G. sylvestre could be due to its antihistaminic, anticholinergic and mast-cell-stabilizing property.

Keywords: G. sylvestre, bronchospasm, mast cell degranulation, compound 48/80.


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