European Journal of Biomedical and Pharmaceutical Sciences

INTERACTIONS OF L-THREONINE WITH AN AQUEOUS ANTI-DIABETIC DRUG SOLUTION AT VARIOUS TEMPERATURES: A VOLUMETRIC APPROACH

Rajagopal K., Shailajha S., Mohamed Roshan M.* and Roy Richi Renold G.

ABSTRACT

Densities ρ, have been measured for L-Threonine in aqueous Metformin Hydrochloride solutions of higher concentrations (0.10, 0.15 and 0.20M) mol kg-1 at T = 298.15 – 318.15K. Apparent molal volumes Vᵩ have been determined from the experimental densities. Several thermodynamical parameters such as standard partial molal volume Vφ0, transfer volume ΔtrVφ0, hydration number nH, the second derivative of infinite dilution of partial molal volume with respect to temperature, viz., ∂2Vφ0 / ∂T2 have been calculated using the density data. Furthermore apparent molal expansibility E0, thermal expansion coefficient, α2 and the pair and triplet interaction coefficients VAD and VADD have been calculated and reported. These results interpreted through a co-sphere overlap model indicate the presence of strong solute-co-solute interactions in the reported systems.

Keywords: Apparent molal volume, standard partial molal volume, transfer volume, hydration number, L-Threonine, Metformin hydrochloride.