Abstract
OPTIMIZATION OF CULTURE CONDITIONS OF STREPTOMYCES ZAOMYCETICUS RC 2073 BY SHAKE FLASK METHOD

Gaurav Naik, Swati Shukla, Ruckminee Mall and Sarad Kumar Mishra*

ABSTRACT

The aim of the present study was to optimization of environmental condition of basal media to support the efficient production of secondary metabolites of novel strain Streptomyces zaomyceticus RC 2073 which exhibits an antimicrobial activity against the Gram-positive and Gram-negative bacteria under in-vitro growth condition. Antimicrobial activity of culture broth was screened by agar well diffusion method against S. aureus. Among different basal media modified Glycerol yeast broth were found best production media for secondary metabolites. Production of secondary metabolites started from 5th days and successively increased upto 9th days then gradually decreases. The maximum production of secondary metabolites was found in the culture medium with initial pH level 7.0 under aerobic condition at temperature 28oC with 10% inoculums size at 200 rpm. The effect of Glycerol as carbon, Peptone with Yeast extract as nitrogen sources and minerals K2HPO4 was proved maximum production of secondary metabolites.

Keywords: Optimization, Secondary metabolites, Glycerol, Streptomyces zaomyceticus.


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