European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF SOLUBILITY ENHANCED MOUTH DISSOLVING FILM OF TELMISARTAN

Bhavana S. Jain*, Dr. Deeliprao V. Derle and Ganesh B. Kedar

ABSTRACT

Telmisartan is BCS Class II drug hence it need to increase its solubility. The present study describes preparation and characterization Solid Dispersion incorporated mouth dissolving film of Telmisartan. By Preparation of solid Dispersion through kneading method Followed by Solvent Casting Method to formulate the MDF. Solid Dispersion is evaluated for Solubility, drug content and drug release rate for screening of Carrier for further formulation. The in-vitro drug release study demonstrated that enhanced the solubility and Rapid drug Release from Solid Dispersion than pure drug. The prepare films were evaluated for their physicochemical and mechanical parameter such as Physical appearance, surface PH, Thickness uniformity, Disintegration time, Drug content uniformity, folding endurance, and In-vitro drug release. The method was optimized by applying 32 level factorial designs. The effects of composition of Film forming polymer and Super disintegration on Appearance of film, disintegrating time, and in-vitro drug release behaviour were investigated the in-vitro Drug Release and Disintegration time of optimized formulation (F7) was found to be 91.83 %, and 29 sec respectively. This optimized batch was studied for its stability for 1 month.

Keywords: Telmisartan, Solid Dispersion, Mouth Dissolving Film, Optimized Batch.