Abstract
SOLUBILITY ENHANCEMENT OF FUROSEMIDE IN MICELLAR SOLUTION OF CETYL TRIMETHYLAMMONIUM BROMIDE

Monika Jain, S. K. Chatterjee and Deepak Sinha*

ABSTRACT

The poor aqueous solubility of drugs is a challenging problem of pharmaceutical industries. Objective of present study was to investigate the increasing solubility of furosemide drug in the presence of cetyl trimethylammonium bromide (CTAB) solution. Furosemide is a drug with diuretic properties. Conductivity measurement have been carried out to study the micellar behavior of CTAB in the temperature range of 25°C–40°C. From the measurements, various physicochemical and surface properties Critical micellar concentration (CMC), thermodynamic parameters (ΔG°m, ΔH°m, ΔS°m) have been determined. The negative value of ΔG°m shows spontaneity of solubilization process. All these parameters have been discussed in terms of drug-drug, drug-solvent and drug-surfactant interactions. This result shows that the solubility of Furosemide drug increases with increasing the concentration of surfactant. This study reveals that use of surfactant in pharmacy is an important tools for finding numerous applications.

Keywords: Micelles; Furosemide; Solubilization; Critical Micellar Concentration.


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