European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF BILAYER FLOATING TABLETS OF AMOXICILLIN AND RABEPRAZOLE

Niveditha Parusarouthu*, Sinduja Manda, Mazbeen Naznin, Bhanuchander Peddhola, Siddulu Regu and Krishna Mohan Chinnala

ABSTRACT

Bilayer floating tablet is made up of two distinct layers compressed together with the individual layers lying one on top of another. In the present research work the bilayer floating tablets were formulated with Rabeprazole in Sustained release layer and Amoxicillin in immediate release layer. These tablets were prepared by both direct compression method and wet granulation method of different formulations (F1, F2, F3, F4, F5, and F6) by using different combinations and ratios of polymers. Evaluation parameters i.e. pre-compression parameters like bulk density, tapped density, Hausner’s ratio, Carr’s index and angle of repose were performed and post compression parameters like weight variation, friability, thickness, hardness, disintegration and dissolution were performed for all these formulations. Among all the formulations, F5 showed an optimized drug release profile. Polymer concentration was adjusted to get the maximum sustained release in 8 h and the effervescent agents were found to give floating lag time of about 1.3 min with total floating time of more than 8 h.

Keywords: Bilayer floating tablet, direct compression, wet granulation, effervescent agents, floating lag time, floating time.