European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF THE ROLE OF TRANSDERMAL NITROGLYCERINE PATCH ON POSTOPERATIVE ANALGESIA.

Dr. Manjulata Shakya and Dr. Subhash Kumar Agrawal*

ABSTRACT

Introduction: Various regimens have been adopted to enhance the reliability of regional anaesthesia, in terms of its hemodynamic stability, rapid onset of blockade and long lasting postoperative pain relief. Our study compared the effectiveness of transdermal nitroglycerine patch for enhancement of post operative analgesia along with bupivacaine heavy injection intrathecaly. Study design: A prospective type of study. Material and Method: Study was carried out in 60 patients divided into two groups each. One received Intrathecal inj. bupivacaine hydrochloride (heavy) 0.5% mg 15 mg along with Placebo patch and other received Intrathecal inj. bupivacaine hydrochloride (heavy) 0.5% mg 15 mg along with Nitroglycerine transdermal patch (25 mg). Results were analyzed. Results and Conclusion: Application of Nitro-glycerine transdermal patch (25 mg) increases the post operative analgesia and decreases the rescue analgesic requirements without any significant adverse effects.

Keywords: Nitroglycerine transdermal patch, spinal anesthesia, postoperative pain.