ANTIMICROBIAL, CYTOTOXIC AND PHYTOCHEMICAL ANALYSIS OF MUSSSAENDA FRONDOSA
Anitha C.* and Sajina Thomas
ABSTRACT
Medicinal plants play an important role in the discovery of novel drugs used in medicine. The Musssaenda frondosa was screened for phytochemical, antimicrobial and cytotoxic activities of the methanol, hexane, petroleum ether and chloroform crude extracts were studied in this work. The preliminary screening of the various extracts revealed the presence of tannin, alkaloids, carbohydrate, saponin, terpenoids, flavonoids and cardiac glycosides. The antimicrobial screening was Carried out using the following organisms; Bacillus subtilis, Klebsiella pneumonia, Bacillus thuringiesis, Proteus vulgaris, Agrobacterium rhizogens, Lactobacillus acidophilus, Bacillus megaterium, Candida tropicalis, Aspergillus niger, Aspergillus aculeatus, Rhizomucor miechei and Saccharomyces cerevisiae. Phytochemical analysis of aqueous extract showed that the presence of tannin, alkaloids, carbohydrate, saponin, terpenoids, flavonoids and cardiac glycosides. Hexane extract showed highest antibacterial activity against Lactobacillus acidophilus and highest antifungal activity against Candida tropicalis. An invitro cytotoxicity test using Test on Extraction method was performed with test sample Mussaenda frondosa and based on ISO 10993-5. This study offers a scope for developing medicines.
Keywords: Musssaenda frondosa, phytochemical analysis, antimicrobial activity, cytotoxicity.
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