REVIEW ARTICLE: SOLID LIPID NANOPARTICLES (SLN) AS A NOVEL DRUG DELIVERY SYSTEM
Ganesh B. Kedar*, Dr. Milind P. Wagh and Bhavana S. Jain
ABSTRACT
Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. Recently, increasing attention has been focused on these SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. The system consists of spherical solid lipid particles in the Nano-meter ranges, which are dispersed in water or in aqueous surfactant solution. It is identical to an oil-in-water emulsion for parenteral nutrition but the liquid lipid (oil) of the emulsion has been replaced by a solid lipid, i.e., yielding Solid Lipid Nanoparticles. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are described. Appropriate analytical techniques for characterization of solid lipid nanoparticles like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases.
Keywords: Solid lipid nanoparticles (SLN), homogenization, Drug released, Preservation, Characterization and Application.
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