European Journal of Biomedical and Pharmaceutical Sciences

POSSIBLE TOXIC EFFECT OF PLANT EXTRACT OF ON MALE ALBINO RAT

Amita Shishodia*, Ajay Kumar Pundir

ABSTRACT

Introduction-Natural products, including plants, animals and minerals have been the basis of treatment of human diseases. History of medicine dates back practically to the existence of human civilization. The current accepted modern medicine or allopathy has gradually developed over the years by scientific and observational efforts of scientists. However, the basis of its development remains rooted in traditional medicine and therapies. The history of medicine includes many ludicrous therapies. Nevertheless, ancient wisdom has been the basis of modern medicine and will remain as one important source of future medicine and therapeutics. The future of natural products drug discovery will be more holistic, personalized and involve wise use of ancient and modern therapeutic skills in a complementary manner so that maximum benefits can be accrued to the patients and the community.( Patwardhan, B. and Hooper, M., Ayurveda and future drug development. Int. J. Alternative Complement. Med., 1992, 10, 9–11.). discussion-The process of apoptosis is controlled by a diverse range of cell signals, which may originate either extracellularly (extrinsic inducers) or intracellularly (intrinsic inducers). Extracellular signals may include toxins,[12] hormones, growth factors, nitric oxide[13,20] or cytokines, that must either cross the plasma membrane or transduce to effect a response. These signals may positively (i.e., trigger) or negatively (i.e., repress, inhibit, or dampen) affect apoptosis. (Binding and subsequent trigger of apoptosis by a molecule is termed positive induction, whereas the active repression or inhibition of apoptosis by a molecule is termed negative induction.) The count was done on haemocytometer.

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