European Journal of Biomedical and Pharmaceutical Sciences

ENHANCEMENT OF DISSOLUTION RATE OF MELOXICAM USING SUPER DISINTEGRATING AGENTS AND SOLID DISPERSION TECHNIQUE

Mohsina Abid*, Fareeaa Ashar, Maliha Abed, Asna Abed and Dr. Fazil Ahmad

ABSTRACT

The aim of the research is to enhance the dissolution rate of meloxicam using superdisintegrants and solid dispersion technique, to know the effect of super disintegrants on the dissolution rate of meloxicam by selecting the best super disintegrant among SSG, CMS, CP by preparing the solid dispersion of meloxicam using PEG 4000 as carrier, to know the effect of combination of solid dispersion technique and superdisintegrants on dissolution rate of meloxicam. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and fever reducer effects. It is a derivative of oxicam, closely related to piroxicam, and falls in theenolic acid group of NSAIDs. It was developed by Boehringer-Ingelheim. Meloxicam starts to relieve pain about 30–60 minutes after administration. Meloxicam inhibits cyclooxygenase (COX), the enzyme responsible for converting arachidonic acid into prostaglandin H2—the first step in the synthesis of prostaglandins, which are mediators of inflammation. To enhance the dissolution rate and its bioavailability, meloxicam is formulated into capsules using super disintegrating agents (SSG, CMS, and CP) and solid dispersion technique. All the formulations are suitable for development of hard capsules of Meloxicam. Compared to all formulations of F-series, F7 was found to yield best results in terms of in vitro dissolution rate. In A-series formulations, A1 shows increased drug release patterns with the fastest in vitro dissolution rate followed by CMS then SSG. The study concluded that the formulation prepared using A- series and F- series, A1 and F7 exhibits better dissolution rate at high concentration of super disintegrating agents.

Keywords: Dissolution, Meloxicam, Super Disintegrating Agents, Solid Dispersion Technique, Non-Steroidal Anti-Inflammatory Drug (NSAID).