Abstract
THE RELATIONSHIP OF THYROID GLAND VOLUME (TGV) WITH THYROID STIMULATING HORMONE (TSH) AND THE QUANTITATIVE MEASUREMENT OF THE VARIATIONS IN TGV IN RELATION TO PER UNIT INCREASE IN SERUM TSH

*Dr. Mahrukh Kamran MBBS, MPhil , Dr. Sahar Mubeen MBBS, MPhil, Dr. Iffat Raza MBBS, MPhil, Dr. Sanobar Bughio MBBS, MD, Hira Waseem and Dr. Zainab Khalique Ansari BDS

ABSTRACT

Introduction: Thyroid gland (TG) secretes thyroid hormones that are essential for physical growth, mental development and metabolic homeostasis. Thyroid Stimulating Hormone (TSH) plays an important role in controlling thyroid gland volume (TGV) due to its mutagenic effects on thyroid follicular cells. Objectives of this study are to determine the relationship between thyroid gland volume (TGV) and serum TSH and also to measure the amount of variation that take place in TGV due to per unit increase in serum TSH levels in Karachi population. Methodology: It was a cross sectional study in which serum TSH level of 128 subjects was evaluated. TGV was determined through ultrasonography. Linear Correlation and regression analysis between TGV and serum TSH level was then analyzed on SPSS version 21. P=Value <0.05 was considered significant. Results: Mean value of serum TSH of 128 subjects was 1.777 μI/ml ± 1.108 μIU/ml. Significantly negative correlation was observe between serum TSH and total TGV (P Value =0.03) and right lobe volume (P-Value =0.029). Through regression analysis it was determined that 3.7% of total variation in total TGV and also in right lobe volume are due to serum TSH. However the effect of serum TSH on left lobe volume of thyroid was found to be insignificant (P-Value =0.067). Conclusion: Correlation between Serum TSH and TGV demonstrated negative but significant effects on total TGV and right lobe volume. Regression analysis demonstrated with per unit increase in serum TSH, total TGV and right lobe volume decrease significantly. More detailed studies may accurately determine the volume of thyroid gland for the known level of serum TSH.

Keywords: Thyroid Gland, Thyrotropin, Diagnostic imaging.


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