European Journal of Biomedical and Pharmaceutical Sciences

THE RELATIONSHIP BETWEEN CARDIAC RISK FACTORS AND TOTAL BILIRUBIN LEVELS IN PATIENTS WITH CHRONIC RENAL FAILURE

Eren Düzgün, Hilal Alpcan, Ali Gürel* and Yusuf Kemal Arslan

ABSTRACT

Chronic kidney disease (CKD) is a worldwide public health problem with increasing incidence and prevalence, poor outcomes and high cost. CKD is closely related to cardiac diseases and cardiovascular disease increases the risk of the negative consequences in patients with CKD. Cardiovascular disease is the main cause of morbidity and mortality in patients with CKD and end stage renal disease (ESRD). In our study, we aimed to determine the relationship between cardiac risk factors and serum total bilirubin in 99 patients with glomerular filtration rate (GFR) less than 60 ml/ min/ 1.73 m2 who did not receive renal replacement therapies (RRT) and 94 patients undergoing hemodialysis (HD). The research is planned retrospectively and the demographic characteristics and labaratory values were evaluated. The relationship between these parameters and total bilirubin levels was investigated. In our study, all Framingham cardiovascular risk scores were observed to be lower in patients with high total bilirubin levels. However, these differences in mean scores were not statistically significant. Total bilirubin levels were not significantly different between hemodialysis patients and non-hemodialysis patients. The mean values of triglyceride, RDW, neutrophil / lymphocyte ratio, sCRP, parathormon and phosphorus parameters were higher in hemodialysis patients than in non-hemodialysis patients. The higher mean values of the cardiovascular risk parameters in hemodialysis patients are thought to be associated with a higher rate of cardiovascular events than in non-hemodialysis patients. Patients without hemodialysis treatment had lower total bilirubin levels when GFH was lowered. As a result, total bilirubin has been found to be protective effects against cardiovascular diseases and renal damage.

Keywords: Chronic Kidney Disease, Cardiovascular Disease, Total Bilirubin Level.