European Journal of Biomedical and Pharmaceutical Sciences

Mycobacterium tuberculosis AND ITS RESILIENCE

Kanchan Srivastava, Apoorva Narain and Surya Kant*

ABSTRACT

Drug resistant pathogens today are emerging and spreading more rapidly than in previous decades. These organisms are widespread but also occur increasingly in the community, affecting developed and developing countries, and rapidly spreading through international travel. The increase in microorganisms that have developed resistance to currently available antimicrobial agents has become a major cause for concern worldwide. Some of these strains are multi drug resistant/ total drug resistant and the agents available to treat infections caused by them are few and dwindling. Over recent years there have been a number of responses by national, international and professional bodies to this situation, many aimed at curbing this unprecedented growth in resistance, but there is an increasing recognition that a major problem in the management of infections caused by such organisms is the paucity of new drugs, the problem of resistance to antimicrobials was complex and that multiple solutions would be required. Treatment of infections caused by resistant microbes is increasingly hampered either by the prohibitive cost of existing ‘new generation’ agents or by a total lack of effective antimicrobial agents.

Keywords: Tuberculosis, Drug resistance, diagnostics, Vaccine.