European Journal of Biomedical and Pharmaceutical Sciences

IN-SITU OCULAR GEL - A NOVEL APPROACH TOWARDS OCULAR DRUG DELIVERY

Wadhwa Karan*, Sharma Chandan, Goswami Manish, Thakur Nishant

ABSTRACT

Conventional ocular drug delivery systems like eye drops, ointments, suspensions has various disadvantages of lacrimation, blurred vision and most important rapid precorneal elimination. So in order to overcome these drawbacks various novel approaches were developed such as in situ gel, ocusert, minidisc, collagen shield, nanosuspension, ocular film, nanoparticulate system, ocular iontophoresis, niosomes liposomes,, dendrimers, etc.. In situ ocular gel is one of the recent advancement in ocular drug delivery system. In situ ocular gel system comprise delivery vehicle composed of polymers (natural, semi synthetic or synthetic) which has a special property of sol-gel conversion when influenced by some biological stimulus such as pH, temperature and ions. In situ ocular gels are evaluated for various parameters such as physical appearance, drug content, pH, clarity, gelling capacity, isotonicity evaluation, in vitro drug release studies, viscosity, sterility testing, accelerated studies, texture analysis and irritancy test.

Keywords: In situ ocular gel, Novel ocular dry delivery.