European Journal of Biomedical and Pharmaceutical Sciences

CO-RELATION OF THYROID DISORDERS IN CHRONIC KIDNEY DISEASE

Syed Najeemuddin, Oluseyi Abidoye*, Milisha Lal, Vrushali Dhongde, Abdel Kareem Jamal Al Dabbas, Bhargav Muppaneni, Rono Korra, Sarah Walter John, Stephanie Ogbonda

ABSTRACT

Introduction: Thyroid hormones have a significant effect on the functioning of kidneys. This is due to pre-renal as well as renal effects on kidneys. Decreased GFR is seen in hypothyroidism and increase in GFR and increased Renin-Angiotensin-Aldosterone system is seen in hyperthyroidism. Many researchers have proposed a co-relation between incidence of primary hypothyroidism and subclinical hypothyroidism. In this study, we tried to find the co-relation of thyroid hormones in chronic kidney disease. Methods: In this study, we took 248 patients with GFR ranging from 90 to 30 mL/min/1.73m2. Serum Creatinine and GFR was measured in all the participants. Patients with kidney transplants and patients on dialysis were excluded from the study. Proper physical examination etc was done of all the participants. All data was recorded and analyzed statistically. Results: A total of 248 participants were taken. TSH and T4 levels of all the participants were measured. TSH levels were used as diagnostic criteria for hypothyroidism. Hypothyroidism was defined when TSH levels were >4.5μg/dL or the patient was on taking any thyroid supplement. Subclinical hypothyroidism was measured by TSH levels >4.5μg/dL and total T4 levels as ≥4.5 μg/dL. Baseline characteristics are depicted in table 1. GFR and co-relation of GFR with thyroid levels are depicted in table 2. As GFR decreased, the prevalence of hypothyroidism increases. P value was calculated by multiple logistic regression analysis. P value is 0.0036. Hence, the co-relation is statistically significant. Conclusion: This study shows a positive co-relation between reduced GFR and higher prevalence of hypothyroidism along with subclinical hypothyroidism.

Keywords: Thyroid, Creatinine, hypothyroidism.