European Journal of Biomedical and Pharmaceutical Sciences

SPECTROPHOTOMETRIC DETERMINATION OF AN AZILSARTAN MEDOXOMIL DRUG IN BULK AND PHARMACEUTICAL FORMULATIONS

Ritika Makhijani*, Vighnesh Nalawade, Divyadarshni Balasubramaniam and V. D. Barhate

ABSTRACT

A new simple, precise, sensitive, accurate and reproducible spectrophotometric method have been developed for determination of azilsartan medoxomil(Azutan) in pure and dosage forms. Method is based on oxidation of drug with 1, 10 phenanthroline producing orange colour chromogen which is measured at 510 nm. Beer’s Law is obeyed in the concentration range of 1.0 -7μg/ml. for the developed method. The molar absorptivity and sandell’s sensivity are found to be 0.59 X 10 4 L mol-1cm-1 and 0.0733 μg/cm2 respectively. Different experimental parameter affecting the colour development and stability of coloured products are carefully studied and optimized. The developed method could be successfully applied to pharmaceutical formulations. The result obtained are in good agreement with those obtained using standard method.

Keywords: Azilsartan medoxomil, spectrophotometric method 1,10 phenonthroline.