EVALUATION OF MARKERS AND ANTIOXIDANTS IN BOERHAVIA DIFFUSA FOR CARDIOPROTECTIVE ACTIVITY
A. Shanmugapriya and S. Maneemegalai*
ABSTRACT
Cardiovascular disease (CVD) is the principle cause of death in both developed and developing countries.CVD includes coronary heart disease, congestive heart failure, stroke and Myocardial infarction(MI). MI is the interruption of blood supply to the heart, causing heart cells to die, due to occlusion of coronary artery. Several medicinal plants are available that exhibit significant curative properties for the treatment of cardiovascular disorders. Various research studies on medicinal plants have been going on to prevent the mortality caused by cardiovascular disease. The objective of the present study was to evaluate the cardioprotective role of ethanolic extract of Boerhavia diffusa in increasing concentrations. Myocardial infarction (MI) was experimentally induced by isoproterenol in rats. Serum markers, lipid profile, lipoproteins and antioxidants were analyzed in experimental rats. Administration of Boerhavia diffusa ethanolic extracts restored the levels of marker enzymes like Aspartate Transminase (AST), Alanine Transaminase (ALT), Acid Phosphatase (ACP) and Alkaline Phosphatase (ALP) in increasing concentration. Lipid profile and the level of lipoproteins exhibited significant changes in serum of plant co treated experimental rats. Also, a significant (P<0.05) increase in antioxidants like SOD, Catalase, Glutathione peroxidase and Glutathione reductase were observed in the heart tissue of plant treated groups. The present study can be concluded that the ethanolic extracts of Boerhavia diffusa exhibited significant cardioprotective potential in increasing concentration which might be due to its antioxidant property and membrane stabilizing action.
Keywords: Boerhavia diffusa, antioxidants, cardioprotective, Isoproterenol.
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