A PROSPECTIVE OBSERVATIONAL STUDY ON QUALITY OF LIFE, ADVERSE DRUG REACTIONS AND PRESCRIPTION PATTERN OF PATIENTS UNDERGOING ANTIRETROVIRAL THERAPY
Saleena P. T.*, Nelvin Sunny, Mohammed Safeer K., Neha Saji, Stephy Devassikutty and Basavanna P. L.
ABSTRACT
Background: HIV/AIDS affect communities in every sector of the world making the disease openly an issue of global significance. Number of people living with HIV is 1.99 Lacs in Karnataka, and it holds the third place in India among the states. Objectives: The main objective of the study was to assess the quality of life, adverse drug reactions and prescription pattern among HIV/AIDS patients undergoing Antiretroviral Therapy. Materials and Methods: Study was carried out at ART department, Mysore Medical College & Research Institute and Associated Hospitals; K R Hospital, Mysuru, India, from October 2017 to March 2018. A total of 255 patients were enrolled in the study as per inclusion and exclusion criteria. Patients demographic data were collected by using patient data collection form and Adverse Drug Reactions were assessed by using Naranjo causality assessment scale, Hartwig scale. The Quality of Life was assessed by using WHO QOL-HIV BREF questionnaire. The domains associated with the quality of life were identified and correlated with multiple factors. Results: Majority of the patients were in the age group of 55-64 years. The frequently assessed opportunistic infection was tuberculosis. Lactic acidosis was most commonly seen as ADR. From QOL assessment the „environmental score‟ shows higher QOL. 48.91% ADR were “probable and most of the ADRs are mild (50%). Conclusion: The study was conducted to enhance the overall quality of life among infected individuals. A decline in infection can be obtained by giving education and awareness about the disease in the population.
Keywords: HIV/AIDS, Adverse drug reaction (ADR), Quality of life (QOL). Anti Retroviral Therapy (ART).
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