Abstract
SYNTHESIS OF THIAZOLE SCAFFOLDS BY NOVEL METHOD AND THEIR IN VITRO ANTHELMINTIC ACTIVITY AGAINST INDIAN ADULT EARTHWORM

Dattatraya G. Raut, Vikas D. Kadu, Vikas D. Sonawane, Raghunath B. Bhosale*

ABSTRACT

A highly efficient and facile method has been described for the synthesis of substituted thiazoles and 2-aminothiazoles from phenacyl halide and thiourea in methanol using iodine as a catalyst at ambient temperature and product obtained in excellent yield within short time. The formation of these compounds was confirmed by IR, 1H NMR, 13C NMR and mass spectroscopy. The synthesized different substituted thiazoles (3a-3g) were taken for anthelmintic activity against Indian earthworm Pheretima posthuma at two concentration (50 mg/ml and 100 mg/ml) and results were expressed in terms of time for paralysis and time for death of worms. The albendazole (20 mg/ml) was used as reference standard. The products were evaluated for anthelmintic activity to develop anthelmintic agent. Some of the compounds showed good anthelmintic activity (3g) as compared to albendazole.

Keywords: 2-Aminothiazole, Iodine, Methanol, phenacyl halide, Anthelmintic activity.


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