European Journal of Biomedical and Pharmaceutical Sciences

2-(2-ACETOXY BENZAMIDO)-3-(ALLYLTHIO) PROPANOATE SODIUM FLOCCULATED COARSE SUSPENSION: FORMULATION DEVELOPMENT AND EVALUATION

K. Vadivel*, S. Manohar Babu and P. Muthusamy

ABSTRACT

The main objective of this study is to develop oral flocculated coarse suspension of 2-(2-acetoxy benzamido)-3-(allylthio)propanoate sodium and to evaluate their stability using standard methods. We determined various physicochemical properties like solubility, melting point, drug polymer interactions as a part of pre-formulation study. Different formulations were prepared as deflocculated suspension in structured vehicle with different concentration of wetting agents (DFS1-4), Flocculated suspension in structured vehicle with different concentration of flocculating agent (F1-5) and Flocculated suspension in structured vehicle with different concentration of suspending agent (FS1-5). We performed the evaluation tests like sedimentation volume, the degree of flocculation, redispersibility, flow rate, particle size, drug content and drug release for the prepared formulation. Stability studies on selected suspension (F-4 & FS-2) were conducted for 6 weeks at room temperature. The drug polymer interaction study revealed that there is no interaction between drug and sodium CMC. By increasing the concentration of sodium carboxymethylcellulose in suspension, improved the physical stability up to 0.1%. A good correlation between the extent of flocculation and sedimentation volume could be seen in all the flocculated systems of 2-(2-acetoxy benzamido)-3-(allylthio)propanoate sodium suspension. Among the formulated suspension, FS-2 showed better physical stability so it was identified as the best formulation.

Keywords: 2-(2-acetoxy benzamido)-3-(allylthio)propanoate sodium, DSC, FTIR, redispersibility, sedimentation volume, drug content, drug release.