European Journal of Biomedical and Pharmaceutical Sciences

GENETIC STUDY OF GENE TNF- ? AND IL-1? ASSOCIATED POLYMORPHISMS WITH PRETERM BIRTH

Rashi Shukla* and Rashmi Arnold

ABSTRACT

Due to the widespread belief of the role of pro-inflammatory cytokines in preterm birth and limited availability of study data of TNF-α and IL1β gene polymorphisms. The aim of the current work was to systematically review the available literature for the association of TNF-α and IL1β polymorphisms with preterm birth, replicate the association on an Indian population and combine data from the findings using Meta-analysis. TNF-α (-308G/A) and IL-1β (-511C/T) has been involved in the preterm mechanism. Our efforts were to replicate and Meta analyze the currently available data linking TNF-α polymorphism and IL-1 β to preterm birth. The included studies in this review were a) Association of TNF-α and IL-1β case-control design. Many alterations in inflammatory pathway can be triggered by the activities of TNF-a, mainly those leading to the amplification of immunologic and inflammatory processes. Evidences have supported that increased concentration of TNF-α in amniotic fluid has been associated with Preterm birth and preterm premature rupture of membranes.

Keywords: Preterm Birth, Proinflammation, Inflammation.