THE PHYTOCHEMICAL INVESTIGATION, ISOLATION AND EVALUATION OF ANTI-PARKINSONIAN ACTIVITY OF RHIZOME OF DELPHINIUM DENUDATUM WALL IN RATS
*Syed Shah Abdus Salaam, Fatima Nooreen, Mohsina Abid, Priyanka Polavarapu and Dr. Fazil Ahmad
ABSTRACT
The study was aimed to explore the anti-Parkinsonian (catatonian) potential of Delphinium denudatum wall in animal model. Delphinium species, annual or perennial, erect and hardy ornamental herbs are grown for their beautiful flowers. Delphinium denudatum wall is recommended for disorders like epilepsy, tremors, paralysis, facial paralysis, convulsions, chronic coryza, sinusitis, numbness, scorpion bite, etc. Qualitative phytochemical analysis of the ethanolic extract of Delphinium denudatum wall rhizome showed the presence of alkaloids, phenol, tannins, steroids, proteins, amino acids, carbohydrates, fats and oils in the ethanolic extract of Delphinium denudatum wall rhizome. The anti-parkinsonian activity of Delphinium denudatum wall rhizome was evaluated by drug induced catatonia method in Wister albino rats. Haloperidol was used to induce catatonia in rats and Bromocripitine was used as standard. It was observed that the % inhibition of catatonia after 30 minutes of haloperidol administration in group II, III, IV and V were 87, 74, 78 and 83 respectively. The observation was recorded for 2 hours and it was observed that there is decrease in duration of catatonia in group II, III, IV and V which was statistically more significant. The results suggested that the ethanolic extract of Delphinium denudatum wall rhizome showing anti-parkinsonianian activity. Hence, it can be safely administered in anti-parkinsonian patients with minimal effects.
Keywords: Anti-Parkinsonian, Delphinium denudatum wall, catatonian, Haloperidol, Bromocriptine, Wister Albino rats.
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