FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF TOLMETIN SODIUM
Dr. B. Sree Giri Prasad*, Kuthadi Priyanka, G. Ramesh, G. Sravani, L. Nikhil Kumar, M. Akhil, V. Sail Prashanth, Krishna Mohan Chinnala
ABSTRACT
Transdermal films, employing Hydroxy Propyl Methylcellulose and Ethyl cellulose as film formers were developed for Tolmetin Sodium. The effect of HPMC K4M alone, binary mixture of HPMC K4M: EC and type of chemical penetration enhancers on physicochemical parameters including thickness, moisture content and moisture uptake was evaluated. Drug– Polymer Interaction studies were carried out using Fourier Transfer Infrared spectroscopy method. In-vitro permeation study was conducted using cellophane membrane as penetration barrier in modified Keshary-Chein diffusion cell. The drug content was high and uniformly distributed in films. Moisture uptakes were found to increase with increasing concentration of hydrophilic polymer (HPMC K4M). During in-vitro skin permeation studies, it was found that, HPMC K4M: EC showed highest flux, and EO has more enhancing effect compared to DMSO on permeation of Tolmetin Sodium across cellophane membrane. Analysis of release kinetics and mechanism of drug release, revealed that all the formulations follow apparent zero order release kinetics and drug release in HPMC K4M : EC binary mixture followed non-Fickian diffusion (n>0.5). Based on the above observations, it can be reasonably concluded that HPMC K4M: EC combination and penetration enhancer, EO are better suited for the development of TDDS of Tolmetin Sodium.
Keywords: Transdermal Films, Tolmetin Sodium; Ethyl Cellulose, Hydroxy Propyl Methyl Cellulose, In- vitro Permeation.
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