European Journal of Biomedical and Pharmaceutical Sciences

ASSOCIATION BETWEEN D- DIMER LEVEL AND MALARIA INFECTION AMONG SUDANESE PATIENTS IN KHARTOUM STATE 2017

Tarig A. M. Hamid*, Zeinab S. A. Alsayed, Sarah M. D. Ahmed, Hind A Mahmoud

ABSTRACT

BACKGROUND This prospective case control study was aimed in assessing the presence, severity, and correlate the pathogenesis of blood coagulation disorder (hypercoagulability) often associated with malaria in patients that have the disease. AIM in order to evaluate the effect of hypercoagulability by using D-Dimer among various categories of Sudanese malaria patients in Khartoum state. METHOD Trisodium citrate anticoagulated venous blood was collected from patients with malaria and centrifuged for 15 minutes at 2000g and plasma was separated from the sample, the plasma sample was kept frozen at -20oc for 2 weeks, thawing of plasma was performed at 37oc for 15 minutes in order to obtain platelet poor plasma. The platelet poor plasma samples were measured by using d-dimer test device (IchromaTM) to evaluate the cross-linked fibrin degradation product containing D-Dimer in the patient plasma. RESULTS A total of 40 blood samples were included, 30 of these samples were collected from patient with malaria infection included as a case group and 10 samples were collected from apparently normal individuals included as a control group. The samples were collected from different age and sex groups, child >14 years and adult (15 – 37) years, 23 males and 17females. The study population divided into two group depend on the malaria parasite species, patient who’s infected with P. vivax, and other twenty seven patient infected with P. falciparum. Present study showed a significant decrease of d dimer level associate with the age groups (P; 0.00), and was slightly decreased in a female group compared with male group with significant (P; 0.02). D dimer level was elevated in vivax group compared with falciparum group with statistical significant (P; 0.00) .CONCLUSION The present study concluded that Malaria patient have a hypercoagulable status, with increased risk of thrombosis which is more in female, adult and falciparum infected patient compare with males, child and vivax infected patient respectively.

Keywords: Malaria infection, d-dimer.