European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF POLYHERBAL ANTI ULCER TABLETS

Tejendra Saikia*, Dr Biswajit Das and Dibyendu Shil

ABSTRACT

The aim of the present study was to formulate and evaluate polyherbal tablets having floating property to cure ulcer. Oral route of administration of drug is more popular due to its easy administration and more patience compliance. Although in some cases like ulcer conventional tablets are not so effective when a local delivery of drug and a longer gastric retention time is desired in the stomach. In the present study different herbs having anti ulcer property are selected based on the literature survey. Hydroalcoholic extract of Leaves of Aadirachta indica, fruits of Terminalia chebula and Shankha bhasma were used to formulate the floating tablets. HPMCK 100 and Carbopol 934 were used as polymer. Tablets were prepared by wet granulation method. Different pre compression parameters like bulk density, tapped density, angle of repose were measured. Post compression parameters like swelling index, floating lag time, floating time were measured.

Keywords: Polyherbal formulation, Floating tablet, Ulcer.