*Nuziha Thasneem and Dr. P. Rajasulochana


Diabetes mellitus can be identified by chronic hyperglycemia and impaired carbohydrates, proteins metabolism and lipids due to complete or partial inadequate of insulin secretion and/or insulin action. In general, there are two varieties of diabetes, namely, (i) type 1 diabetes mellitus, T1DM - insulin-dependent diabetes mellitus and (ii) type 2 diabetes mellitus, T2DM - non-insulin-dependent diabetes mellitus. Type 2 diabetes is observed to be the general form of diabetes mellitus, which exists in 90% to 95% of all diabetic patients. For the last few decades, the demand for herbal medicines is being increased due to its biological values, higher safety margin and lesser costs than the synthetic drugs. In the present study, for type 2 diabetes, the gene responsible for the insulin resistance gene from the genomic information resource database was identified. The gene is further analysed and docked with the four herbal components and checked its minimum energy value for further studies. This will be the combination of drug and using Nano medicine which will be the target drug delivery towards the target gene which stimulates the activity of the insulin resistant gene. Since its targets towards the gene, it will be considered as the gene therapy and new combinatorial medicine, here Bioinformatics, combinatorial chemistry, pharmacology, Nano medicine play a vital role in treatment of diabetes.

Keywords: chronic hyperglycemia and impaired carbohydrates.

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