European Journal of Biomedical and Pharmaceutical Sciences

AN OBSERVATIONAL STUDY TO EVALUATE THE PREVALENCE AND ANTIBIOTIC RESISTANCE PATTERN OF URINARY TRACT INFECTION IN A TERTIARY CARE HOSPITAL

Chandrashekar K. R.*, Rosy Raju, F. Laltlanthangi, Manisha Devi, Eby Mathew, Hanumanthachar Joshi and Basavanna P. L.

ABSTRACT

Urinary tract infection is one of the prevailing infections affecting worldwide. Its clinical characteristics and susceptible rates of bacteria are important in determining the treatment of choice and duration. This study aimed to determine the prevalence, aetiology, risk factors and the pattern of antibiotic resistance of uropathogens from patients in a tertiary care hospital. A total of 102 cases were collected. All relevant data were collected and documented in a suitably designed data collection form and the prevalence and risk factor were assessed. The data with regard to culture and sensitivity of the organisms isolated from patient’s urine were collected from reports of laboratory from which causative uropathogens and their resistance pattern were assessed. Out of 102 urinary tract infection cases 67 were females and 35 were males. A total of 73 positive samples were evaluated; Escherichia coli was the predominant isolates (72.6%) followed by Klebsiella pneumonia (13.6%), Pseudomonas aeruginosa (8.2%) and Citrobacter (5.47%). Antibiotics which showed high resistance to uropathogens were amoxicillin, cephalexin, chloramphenicol, nalidixic acid, tetracycline and cotrimoxazole. In this study Escherichia coli was the predominant bacterial isolate and all isolates showed more sensitivity to nitrofurantoin, ceftriaxone and amikacin. Thus, these drugs may be used as an empirical therapy for urinary tract infection.

Keywords: Prevalence, Antibiotic resistance, Urinary tract infection, Escherichia coli.