Abstract
FORMULATION AND EVALUATION OF DOXORUBICIN HYDROCHLORIDE LOADED BOVINE SERUM ALBUMIN NANOPARTICLES

Bharathi Agirela*, Poojitha Chimata, Chandra Sekhar Naik D., Harika Cherukuri and Nandini Akula

ABSTRACT

Nanoparticles are small colloidal particles measuring 100 nanometers which were simple, stable and easy to scale-up. The nature of many conventional drugs changes when converted to nanoparticles. Nanoparticles have more surface area than larger particles which makes them more reactive (protecting against chemical and enzymatic degradation, ability to reduce side effects). Doxorubicin Hydrochloride is one of the commonly used drugs for the treatment of the metastatic breast cancer or ovarian cancer. In this study, Albumin was used to prepare Nanoparticle, in different compositions and particles were numerous and Nano metric in size. To formulate Doxorubicin Hydrochloride encapsulated nanoparticles. To assess the impact of polymer ratio, surfactant and homogenization speed on particle size, entrapment efficiency and in vitro release of Doxorubicin Hydrochloride. The linearity was demonstrated by 50, 75, 100, 125 and 150% of the normal concentration of 0.5mg/mL using 5 concentrations between these ranges. These concentrations were prepared by coacervation method. Based on the entrapment efficiency and particle size a set of formulations (F11, F19 and F21) were considered as lead formulations which are evaluated for the diffusion studies. By observing the results it can be concluded that the formulation F19 has the ability to prolong the release and reduce the side effects by targeting the drug to the desired site and reduce the dosing frequency of the drug for better patient compliance.

Keywords: Doxorubicin Hydrochloride, Serum albumin, Nanoparticle, Entrapment efficiency, Linearity.


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