European Journal of Biomedical and Pharmaceutical Sciences

INFLUENCE OF AGE AND GENDER ON RENAL FUNCTION BY USING eGFR IN HEALTHY POPULATION

*S. Akila, P. Pullaiah, R. Deepti and L. Ramesh Bharathi

ABSTRACT

Background: Prevalence of chronic kidney disease is increasing and became one of the biggest health problem around the globe. Researchers in western countries had done researches on estimated glomerular fitration rate (eGFR) to diagnose the kidney disease at the initial stages and to prevent the progression of the disease. Indian population eGFR values varies from the western population eGFR. Aim: To evaluate the eGFR calculated using Modification of diet for renal disease (MDRD) formula in different age groups of healthy Indian individuals and observe the association between eGFR and age, gender in healthy Indian population. Material and Methods: A total of 410 healthy individuals of age from 31 to 70 years were selected and divided into four groups accordingly to the age. Group I – 31 to 40 years, Group II – 41 to 50 years, Group III – 51 to 60 years and Group IV – 61 to 70 years. Serum creatinine levels was estimated by Jaffe’s method. eGFR was assessed by MDRD formula. Results: We observed a statistical significances between both the genders in the group I (p < 0.001), group II (p < 0.001), group III (p < 0.05) and group IV (p < 0.001). Females mean value of eGFR is slightly lower than the eGFR mean value of males. Discussion: Among 410 healthy individuals age from 31 to 70 years, majority of the individuals have eGFR value less than 90 ml/min in both genders. Elderly individuals normally had low eGFR compared to adult individuals in many studies. Low eGFR value in elderly people should not be misdiagnosed as kidney disease. Conclusion: eGFR calculated using MDRD formula highlights the importances in diagnosing kidney disease except in elderly individuals.

Keywords: eGFR, MDRD formula and kidney disease.