European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS AND EVALUTION OF MUTUAL PRODRUGS FROM CLOPIDOGREL ANALOGUES AND SALICYLIC ACID

Asnani A. J.*, Patari S., Chaple D. R. and Pratyush K.

ABSTRACT

A series of 4,5,6,7- tetrahydrotheino[3,2-c]pyridine derivatives having structure analogs to clopidogrel was synthesized and prepared their mutual prodrug with salicylic acid and evaluated for anti-platelet and antithrombotic activity. The confirmation of structure was done by IR, NMR, and Mass fragmentation. All synthesized mutual prodrug were subjected to investigation for their anti-platelet and antithrombotic activity using clopidrogrel and aspirin as the standard drugs alone or in combination, synthesized mutual prodrug of clopidogrel analogues and salicylic acid shows better activity as compared to standard drugs.

Keywords: Clopidogrel, salicylic acid, anti-platelet activity and antithrombotic activity.