European Journal of Biomedical and Pharmaceutical Sciences

DESIGN AND SYNTHESIS OF NOVEL 1,3,4-OXADIAZOLE AND 1,2,4-TRIAZOLO[3,4-B]1,3,4-THIADIAZOLE DERIVATIVES AND THEIR ANTIMICROBIAL STUDIES

Settypalli Triloknadh, Chunduri Venkata Rao*, Begari Nagaraju, Hari Balaji and Meriga Balaji

ABSTRACT

Design and synthesis of a series of 2,4-dinitro phenyl ring containing 1,3,4-oxadiazole and 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole derivatives. All of the compounds were characterized well by spectroscopy analysis (1H-NMR, 13C-NMR, FT-IR and LC-MS) and they were evaluated for their antimicrobial activity against four bacterial and three fungal strains using paper disc diffusion technique.

Keywords: 1,3,4-oxadiazole, 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole, Antimicrobial activity.